🧬 Protein Analysis Report P15018

Comprehensive biophysical and structural analysis

Protein Name
Leukemia inhibitory factor
Gene Name
LIF
Organism of Origin
Homo sapiens
UniProt Accession
P15018
Sequence Length
202 amino acids
Annotated Features
0 from UniProt
Amino Acid Sequence:
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Computed Biophysical Properties

Calculated using BioPython ProtParam with Bjellqvist pKa values

Molecular Weight
22.01kDa
GRAVY Score
0.076
Aromaticity
6.93%
Instability Index
21.67Stable
Cysteine Count
6residues
Disulfide Bonds
3confirmed
Extinction Coeff (Reduced)
15930M⁻¹cm⁻¹
Extinction Coeff (Oxidized)
16305M⁻¹cm⁻¹
Secondary Structure Predicted (%) Experimental (%)
Helix (α) 32.67 54.46
Turn (β-turn) 28.71 2.97
Sheet (β) 39.11 4.46
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pH-Dependent Charge Profile

Net charge of the protein across pH range 2.0 - 12.0

Isoelectric Point (pI)
- pH
Charge at pH 7.4 (Physiological)
- e⁻
Charge Range
- to -
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Interactive Protein Viewer

💡 Hover over colored features to see position, length, and Feature ID

Sequence i Amino acid letters (one-letter code)
Hydrophobicity i Kyte-Doolittle scale: Blue=polar, Red=nonpolar
Chain i Mature protein after signal peptide cleavage
Domain i Conserved functional/structural domains
Region i Regions of interest (disordered, coiled-coil, etc.)
Site i Functionally important sites (active site, etc.)
Binding Site i Residues involved in ligand/substrate binding
Disulfide Bond i Cysteine pairs forming S-S bridges
Beta Strand i β-sheet secondary structure elements
Helix i α-helix secondary structure elements
Turn i β-turn secondary structure elements
Modified Residue i Post-translational modifications (PTMs)